T3: It works on rats – and on me

hypothyroidism, chronic, living well with hypothyroidism disease,

New research supports a combination therapy with T4 and T3 or NDT (natural desiccated thyroid). Through a series of experiments with rats and mice, researchers have attempted to elucidate why pure T4 treatment (e.g., thyroxine / synthroid) and blood values ​​in the reference area may not always be able to remove all symptoms in patients with hypothyroidism. And although there are obviously differences between rats and humans, the results and conclusions are quite interesting.


T3 works – and best of all as “slow release” pills

The scientific article is not mistaken. When you read the research and findings, I must say it is, to put it mildly, fairly complex reading. But the researchers’ conclusions are not mistaken: there are real good scientific arguments for supplementing of T3 or NDT for a group of patients. At the same time, the research finds that the supplementation of T3 hormones really works if administered in pills that release hormones slowly and continuously over a day.

The study shows that supplementation with T3 works on rats. In addition, although rats produce much T3 in their thyroid, there is – according to the researchers – a good reason to believe that it works on humans, too.


We kind of knew it already …

It is always nice when research support your own experience, and frankly, we knew in advance that some patients are heavily dependent on supplementation of T3 or treatment with NDT. Fortunately, some doctors have already acknowledged this.

Hopefully, this research can have a positive effect on doctors who still have no knowledge of this, and who so far do not have the courage to change the treatment regimens of patients with hypothyroidism.


We have not achieved the goal yet

I am of course well aware that more scientific studies showing the same results are needed before all doctors can be convinced that a combination with NDT therapy can have a positive effect on some patients. I am also aware that some doctors and researchers have staked their whole research in another direction and that they probably will never be convinced.

My goal is simply that we should be allowed to try a different type of medication if and when we do not get any better on standard therapy with T4-only medication.

What is there to lose if patients already live poor-quality lives due to hypothyroidism?
Let them try T3 or NDT – and follow them carefully throughout the process.

The study showed that a combination therapy worked on rats. And I must say – it is working on me, too. And I know so many people with hypothyroidism that didn’t get their lives back or weren’t able to get rid of many of their symptoms until their treatment regimen was changed, and they then received T3 or NDT.


hypothyroidism, chronic, living well with hypothyroidism disease,

I am living well with hypothyroidism now. I feel great – and healthy, despite the fact that I have a chronic disease.
the medication that works for me is T3 in combination with T4. When I was on T4-only medication I still had all the symptoms of hypothyroidism.


J Clin Invest. doi: 10.1172 / JCI77588.

Differences in hypothalamic type 2 deiodinase ubiquitination explain localized sensitivity two thyroxine

Joao Pedro Werneck the Castro1,2, Tatiana L. Fonseca1,2, Cintia B. Ueta1, Elizabeth A. McAninch1,2, Sherine Abdalla1, Gabor Wittmann3, Ronald M. Lechan3, Balazs Gereben4 and Antonio C. Bianco1,2


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